Smart Students Formulate Cheaper Generic Drug

The ever-increasing costs of prescription medications have made dramatic headlines over the last twelve months.

epipenOne of the more recent and visibly-reported medication increases involved Epipen, the life-saving epinephrine drug used to counteract severe allergic reactions. That drug underwent a 600% price increase over a short period while maintaining a 90% market share due to lack of competition.

Other essential medications also have undergone sharp price increases in the recent past. These include life-saving leukemia-fighting drugs, diabetic medications and anti-clotting pharmaceuticals.

But one of the most dramatic medication price increases in the last year involved a drug called Daraprim, an anti-daraprimparasitic medication used to treat infections such as malaria and toxoplasmosis. When Turing Pharmaceuticals bought the marketing rights to this drug, the price jumped almost overnight from approximately $US13.50 to about $750 per tablet—over a 5000% increase!

Daraprim is on the World Health Organization’s list of essential medications and that stimulated a group of high school students in Sidney, Australia to figure out how such a price increase could be justified and took on a project to prove that there could be a more cost-effective alternative.

The students, working with University of Sydney chemist Alice Williamson, eventually created 3.7 grams of pyrimethamine, Daraprim’s active ingredient, in their high school chemistry lab for about $20—an amount that would sell in the United States for up to $110,000 at the current manufacturer’s list price.

Although the drug is extremely expensive in the United States because Turing Pharmaceuticals controls the exclusive distribution rights in the States through a loophole called “the closed distribution model”, the drug is out of patent and available in most countries around the world for about $1 to $2 instead of the $750 US pricing per tablet.

studentThe students worked through an online research-sharing platform called Open Source Malaria to duplicate the medication in a more cost-effective manner. They even found a safer way to create the drug since the usual manufacturing process of pyrimethamine from raw ingredients involved dangerous reagents not allowed in their high school chemistry lab.

They successfully synthesized the drug in a safer, more cost-effective manner and the resulting medication’s purity was confirmed by spectrograph analysis. Therefore, these industrious students creased a new version of Daraprim—a generic that could compete with the Turing Pharmaceuticals version in the US market.

Unfortunately, any competing drug for Daraprim would have to be compared to the branded drug in extensive clinical trials to receive FDA approval and that would be an expensive and arduous process. The main goal of these students was to prove that a true generic version of this malaria drug could be made inexpensively and they accomplished that.

Hopefully, an inspired generic manufacturer would attempt to useclapping-hands their research and the new technique of engineering this drug since these students were kind enough to publish their manufacturing process fully and free online.

Kudos to this brilliant, selfless group of budding scientists!

Thoughts? Comments? I’d love to hear them!

About James J. Murray, Fiction Writer

With experience in both pharmaceutical manufacturing and clinical patient management, medications and their impact on one’s quality of life have been my expertise. My secret passion of murder and mayhem, however, is a whole other matter. I’ve always loved reading murder mysteries and thrillers, and longed to weave such tales of my own. Drawing on my clinical expertise as a pharmacist and my infatuation with the lethal effects of drugs, my tales of murder, mayhem and medicine will have you looking over your shoulder and suspicious of anything in your medicine cabinet.
This entry was posted in About James J. Murray, Alternative Drug Manufacturing Methods, Blog Writers, Blogging, Daraprim Price Increases, Future Drug Manufacturing Practices, Future of Drug Manufacturing, Future of Prescription Drug Distribution, Generic Drug Manufacturing, Generic Drugs in the US, Generic vs Brand Name Drugs, Increasing Costs of US Pharmaceuticals, Innovative Drug Manufacturing Practices, James J. Murray Blog, Medication Safety Issues, Medication Shortages in the US, Murder Mayhem and Medicine, New Blog, New Drug Manufacturing Methods, New Drug Research, Prescription Drug Safety, Prescription For Murder Blog, Prescription Trends, Synthesizing Inexpensive Generic Drugs, The American Drug Supply, The High Cost Of Medications in the US, Ways To Create More Cost-Effective Generic Drugs and tagged , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

5 Responses to Smart Students Formulate Cheaper Generic Drug

  1. Let’s hope this goes to market, and on sale in the US. The epipen sells for less that $60 a pair in Canada. The guy behind Turing is the worst form of greedy, heartless corporate SOB and gives all corporate executives a bad name. He belongs in jail.

  2. Agreed on all counts, James.
    What?? Epipen is only $60 in Canada? I have one on hand since I have asthma. I think I need to pick up a box in Canada!! I hate to think what it will cost me in the US for a refill, even with just an insurance copay, when mine goes out of date!

    • Oops, I was mistaken about that price, James. My lovely wife needs them. My faulty memory misunderstood. The price is $120 each in Canada; $60 a pair after our insurance pays the rest. You can cancel that trip to Canada now, tho’ I’d be delighted to see you. Still, the Canadian price is much better than Turing’s, especially with the US dollar @ about $1.35 Cdn.

      • Lol – and that’s how rumors get started. What would we do without our wives keeping us honest? Thanks for the info. I’ll need to reorder mine kit since it expires after the first of the year. It will be interesting to compare prices with the Canadian price. I’ll keep you posted!
        All the best for a happy holiday season – stay warm!

      • All the very best to you and yours! First snowfall today.

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